Carbapenem & Colistin Resistance: Why Choose REALQUALITY Carba-Screen?
Antibiotic resistance is a major threat to global health. Carbapenems and colistin are considered the "last-resort weapons" in the treatment of dangerous bacterial infections. To prevent the spread of carbapenem and colistin resistance genes, antibiotic resistance gene testing methods such as REALQUALITY Carba-Screen are a solution attracting great interest from healthcare facilities.
Why Test for Carbapenem and Colistin Resistance Genes?
The Role of Carbapenems and Colistin
Carbapenems are broad-spectrum antibiotics of the β-lactam class that are effective against most Gram-negative bacteria, including Enterobacteriaceae. Carbapenems belong to the reserve antibiotic group and are used only to treat severe bacterial infections when other antibiotic classes are no longer effective.
Colistin is an antibiotic that was discovered in the 1950s; however, because of its high nephrotoxicity, its use was restricted for a long time. Today, with multidrug-resistant bacteria spreading widely, colistin is being used again as a "last resort", especially for carbapenem-resistant infections.
Carbapenem and Colistin Resistance: An Imminent Threat
More and more bacteria carry carbapenemase enzymes such as KPC, IMP, VIM, NDM, OXA, ... These enzymes hydrolyze carbapenems, rendering these antibiotics ineffective. Alongside this is the emergence of MCR (mobile colistin resistance) genes that allow bacteria to resist colistin, creating a major risk that bacteria will break through these last 2 antibiotic lines of defense of humankind.
The Need to Test for Carbapenem and Colistin Resistance Genes
Most carbapenem and colistin resistance genes are located on plasmids, which means they can spread to other bacteria through horizontal gene transfer (transformation, conjugation, ...).
Therefore, timely detection and isolation of patients infected with bacteria carrying carbapenem and colistin resistance genes is extremely important for controlling antibiotic resistance and preventing resistance genes from spreading within hospitals.
Viet Huy's Carbapenem and Colistin Resistance Testing Solution
Figure 1: REALQUALITY Carba-Screen test kit (AB analitica, Italy)
REALQUALITY Carba-Screen (AB analitica, Italy) is a CE-IVD real-time PCR kit that enables rapid detection of carbapenem resistance genes at 2 levels, screening and identification, as well as detection of colistin resistance genes (MCR).
REALQUALITY Carba-Screen (screening) enables rapid screening of carbapenem-resistant infections so that patients can be isolated in time, preventing resistance genes from spreading within the hospital.
REALQUALITY Carba-Screen (identification) precisely identifies which carbapenemase gene is present and also detects the presence of colistin resistance genes (MCR genes), helping clinicians choose the appropriate antibiotic.
In addition, REALQUALITY Carba-Screen was developed to detect most variants of carbapenem and colistin resistance genes, minimizing the risk of missing positive samples.
REALQUALITY Carba-Screen - 03 Core Values
1. The Value of 2-Level Testing:
- Level 1: screens for carbapenem-resistant cases and provides a preliminary grouping of carbapenem resistance genes as class B, class A/D, or Acinetobacter OXA
- Level 2: only for samples carrying class B or class A/D resistance genes; precisely identifies the resistance gene and also detects MCR genes associated with colistin resistance.
2. Automation Capability:
- The kit is available in an automated version for the AB ANALITICA GENEQUALITY systems.
- AB Genius Report software supports automated result analysis
3. Convenient and Safe:
- The kit uses a dUTP/UNG system that limits contamination with residual PCR products from previous test runs. In addition, dUTP/UNG makes it easier to deal with incidents in which PCR products leak into the environment. This gives you peace of mind in any situation.
- Ready-to-use master mix: users need only 2 pipetting steps to prepare the reaction, minimizing errors during work.
4. Contact Us
VIET HUY Technological Scientific Equipment Co., Ltd
- Phone: 0913 605 512
- Email: info@viethuy.vn
- Website: https://viethuy.vn/
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